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KMID : 0358219940210010069
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Korean Journal of Fertility and Sterility
1994 Volume.21 No. 1 p.69 ~ p.76
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Pregnancy and Development Rates of Human Embryos Cryopreserved at Pronuclear and 2-4 cell stages
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양현원
최규완/전한식/차영범/이승재/박종민
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Abstract
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The survival and pregnancy rates were compared between non-frozen embryos and cryopreserved embryos at either pronucleate or 2-4 cell stages using the freezing and thawing techniques being identical in both groups were compared with fresh
embryos.
496
embryos were froze with 1, 2-propanediol and sucrose and 117 2-4 cell stages embryos had been thawed and 79.6 and 66.0% of them respectively were survival. Clinical pregnancy rate was 19.2% for embryos frozen at the pronucleate stage and 19.0%
for
embryos frozen at the 2-4 cell stages while the pregnancy rate of non-frozen embryos was 21.3%. There were no significant difference in the survival and pregnancy rates of embryos frozen at pronucleate and 2-4 cell stages. The current cumulative
pregnancy rate per retrieval in all cycles with frozen zygotes is 35.4%, considerably higher than observed in single transfers of embryos without cryopreservation (21.3%); predicted pregnancy rate after transfer of all frozen embryos is 43.3%. It
is
concluded that firstly, the survival and pregnancy rate of cryopreserved embryos at pronucleate or 2-4 cell stages are very similar to those from their fresh embryos and non-frozen embryos and secondly, cryopreservation substantially enhances
pregnancy
attainment from in vitro fertilization.
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